For the NFL Week 12 'Thursday Night Football' game of Texans vs. Bills , the model is leaning Over the total, projecting 46 combined points. It also says one side of the spread hits in over 50% of simulations. See what it is at SportsLine.

Preview the Week 12 matchup between the Buffalo Bills and Houston Texans with predictions, odds, over/under, spread, betting lines and more.

The Texans had success in containing Josh Allen last season. They'll need to do it again Thursday to keep their playoff hopes alive.

The Houston Texans eye their third consecutive win when they take on the Buffalo Bills in a key 'Thursday Night Football' matchup. Buffalo is coming off a 44-32 win over the Tampa Bay Buccaneers, while Houston defeated the Tennessee Titans 16-13.

The Houston Texans will be without star quarterback C.J. Stroud when they take on the Buffalo Bills on Thursday, as the 24-year-old remains in the concussion protocol.

"Thursday Night Football" expert Sam Schwartzstein joins "The Insiders" ahead of the matchup between the Buffalo Bills and Houston Texans to commence the start of Week 12 of the 2025 NFL season.

HOUSTON — Houston quarterback C.J. Stroud is still recovering from a concussion and will miss a third straight game when the Texans host the Buffalo Bills on Thursday night.

The Bills and Texans will play for the second time in as many seasons on Thursday, and a big weakness is there for Buffalo to feast on.