在生命科学的宏伟叙事中，DNA修复常常被描绘成一个英雄般的篇章。细胞内精密的分子机器夜以继日地巡逻，一旦发现DNA序列上出现断裂，尤其是最凶险的双链断裂 (Double-Strand Breaks, ...

撰文丨王聪编辑丨王多鱼排版丨水成文因纽特人一直保持着捕猎弓头鲸（Balaena mysticetus，一种大型须鲸）的古老传统，他们认为这种鲸鱼“能活人类的两辈子”。后续的相关科学研究都证实了弓头鲸的最长寿命超过 200 ...

Cavefish exhibit resilience to chronic sleep loss and tolerate elevated DNA damage and reduced DNA repair responses without compromising healthspan or longevity.

Artios Pharma, which looking for newer targets that, like PARP inhibitors, affect the way tumors fix themselves, said its ...

Failure to repair DNA damage can result in DNA lesions and mutations that are a driving factors in cancer development. Recent work has identified a function for DNA damage repair mechanism beyond ...

肠道作为人体的 “代谢超级器官”，其健康状态与衰老进程息息相关。随着年龄增长，肠道菌群失衡、肠道屏障功能受损、DNA损伤累积等问题接踵而至，进而引发全身性慢性炎症、免疫功能下降等 “衰老相关病症”，甚至牵连大脑、骨骼等其他器官健康。此次发表的研究，正是瞄准这一核心痛点，深入探索肠道衰老的调控机制，为开发针对性的长寿干预方案提供了全新思路。

Lukas/Bantele团队就打算深入研究，受DNA断裂影响的基因组位点的三维结构和功能。他们首先探究了单个Cas9 DNA双链断裂，是否会影响断裂位点基因的转录活性。他们选择的基因是c-MYC，它位于8号染色体上一个2.8Mb的TAD区域内。他们在覆盖整个c-MYC的TAD区域内的12个Cas9切割位点上分别进行了检测，结果发现c-MYC ...

A new gene-editing technique enables the correction of multiple genetic mutations simultaneously, transforming the prospects ...

Error-prone DNA replication and repair may lead to mutations and cancer in individuals who inherit a mutant copy of the BRCA1 gene, according to a new study by Weill Cornell Medicine investigators.