The endoplasmic reticulum (ER) and mitochondria form contacts that support communication between these two organelles, including synthesis and transfer of lipids, and the exchange of calcium, which ...

The photoreceptors required for post‐translational regulation of CO have been characterized. Mutations in the genes encoding the photoreceptors phytochrome A (phyA) and cryptochrome 2 (cry2) delay ...

Low levels of TP‐primed initiation activity can be obtained in the absence of protein p6 (Blanco et al, 1986). Under these conditions, Spo0A did not have a significant effect (not shown) indicating ...

Over the past decade, several tumor-based predictors of cetuximab efficacy have been identified, yet most function as ...

Sphingosine kinase 1 is an agonist‐activated signalling enzyme that catalyses the formation of sphingosine 1‐phosphate, a lipid second messenger that has been implicated in a number of agonist‐driven ...

Each journal is staffed by professional editors who work in collaboration with one another and our international Editorial Advisory Boards of leading scientists. Please feel free to contact any of the ...

A characteristic structural feature of functional RNAs is the presence of post‐transcriptional modifications. During RNA processing and maturation, RNA molecules undergo various chemical modifications ...

Many small lipophilic compounds in living cells can be modified by glycosylation. These processes can regulate the bioactivity of the compounds, their intracellular location and their metabolism. The ...

While such loss‐of‐function mutagenesis is a powerful approach to the genetic dissection of signal pathways (Glazebrook, 2001), many genes cannot be uncovered in this way because of lethal effects or ...

Mutations in fused in sarcoma (FUS) are a cause of familial amyotrophic lateral sclerosis (fALS). Patients carrying point mutations in the C‐terminus of FUS show neuronal cytoplasmic FUS‐positive ...

MicroRNAs (miRNAs) constitute a novel, phylogenetically extensive family of small RNAs (∼22 nucleotides) with potential roles in gene regulation. Apart from the finding that miRNAs are produced by ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Gli1 + chondrogenic progenitors maintained by ...