We transformed care for advanced prostate cancer, by validating inhibitors of androgen production as an effective cancer ...

Through studies that were amongst the largest of their kind, we identified several genes involved in breast and/or ovarian cancer predisposition such as CHEK2, BRIP1, ATM, PALB2, RAD51C and RAD51D.

We identified many of the cancer-causing chemicals in cigarette smoke and coal tar – including the first pure carcinogen ever to be isolated.

We were the first in Europe to develop chemotherapeutic agents. We discovered, and with The Royal Marsden developed, the chemotherapy drugs busulfan, chlorambucil, melphalan and carboplatin, which are ...

We played an important role in revealing the biochemical steps of the RAS-RAF-MAP kinase pathway. We discovered one of the major ways by which RAS oncogenes cause normal cells to become cancerous – ...

DJ and music promoter, Godfrey Fletcher, was diagnosed with prostate cancer in 2015 at the age of 47, shortly after his father was also diagnosed with the same disease. Since then, Godfrey has made it ...

We applied the principle of synthetic lethality to discover a novel strategy for cancer treatment for patients with BRCA1 or ...

PI3 kinase is a lipid signalling enzyme which plays a key role in the development and progression of many cancers as a result ...

Cancer development is fundamentally an evolutionary process, however monitoring evolutionary dynamics through treatment remains challenging. Our team have recently developed a new methodology that can ...

Drug resistance is a major clinical challenge in cancer treatment, underlying both tumour recurrence and patient mortality (Vasan et al, 2019). Yet when cancer cells develop resistance to a drug, ...