Artios Pharma, which looking for newer targets that, like PARP inhibitors, affect the way tumors fix themselves, said its ...

Cornell researchers have developed a powerful new biosensor that reveals, in unprecedented detail, how and where kinases – ...

Cornell researchers have developed a powerful new biosensor that reveals, in unprecedented detail, how and where ...

WRN inhibitors are attracting increasing attention as a niche but fast-emerging segment within precision oncology, driven by their role in targeting DNA repair vulnerabilities. Promising candidates, ...

Bowhead whales, living over two centuries, defy cancer risks due to exceptional DNA repair, not more tumor suppressors. Researchers found their cells efficiently fix damage, preventing mutations. This ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Poly(ADP-ribose) polymerase 1 (PARP1) is one ...

A body that weighs as much as a small airplane should face steep odds against cancer. You may expect that from a creature ...

A new gene-editing technique enables the correction of multiple genetic mutations simultaneously, transforming the prospects ...

Sir2, an enzyme belonging to sirtuins, has been effectively involved in the deacetylation of proteins. A tandem allosteric effect of reactant and product is responsible for the efficient deacetylation ...

A team of scientists at the University of Seville has identified an essential process that protects DNA integrity in reproductive cells, providing new clues about how organisms avoid genetic defects ...

Summary: A new study shows that the DNA repair enzyme Polβ plays a vital role in protecting the developing brain from harmful mutations. Researchers found that without Polβ, insertion-deletion ...