This valuable work provides new insights into the role of lysine acetylation of alpha-synuclein, the protein involved in Parkinson's Disease. The evidence is mostly solid, but the claims around the ...

Kinesin-1 is a dynamic heterotetrameric assembly of two heavy and two light chains (KHC and KLC) that mediates microtubule-based intracellular transport of many different cargoes. The complex adopts a ...

This study investigates the folding and unfolding behavior of the doubly knotted protein TrmD-Tm1570, providing insight into the molecular mechanisms underlying protein knotting. The findings reveal ...

Genomic evidence from 15th-century Bolivian maize reveals similarity to Central Andean maize from Peru, and pre-Inca and Inca-era breeding that enhanced maize development through selection within ...

This study provides valuable data on the role of Hsd17b7, a gene involved in cholesterol biosynthesis, as a potential regulator of mechanosensory hair cell function. The authors used both zebrafish ...

Children’s social cognitive development emerges from the dynamic interplay of neural maturation, parental caregiving, and dyadic brain-to-brain synchrony.

Unraveling mechanisms underlying post-acute SARS-CoV-2 sequelae (long COVID) and finding therapeutic solutions require a full understanding of the causative role of SARS-CoV-2 persistence and/or ...

The identification of 20 causal plasma proteins for prostate cancer represents a critical step toward addressing the need for improved diagnostic specificity and reveals promising new targets for ...

High-profile news coverage that eLife papers generated in September 2025, including Asia Research News, IFL Science and the Times of India.

The authors investigated the epigenetic mechanisms regulating the differentiation of circulating monocytes that infiltrate the CNS and adopt microglia-like characteristics. The work is useful to the ...

Evidence that learned avoidance of a pathogenic bacterium can be transmitted to future generations in C. elegans is growing.

Trained immunity is reshaping our understanding of host defense by demonstrating that innate immune cells once thought to lack memory can be reprogrammed to mount heightened responses to subsequent ...