We applied the principle of synthetic lethality to discover a novel strategy for cancer treatment for patients with BRCA1 or ...

We played a major role in revealing the biochemical steps of the RAS-RAF-MAP kinase pathway. We identified one of the major ...

PI3 kinase is a lipid signalling enzyme which plays a key role in the development and progression of many cancers as a result ...

We transformed care for advanced prostate cancer, by validating inhibitors of androgen production as an effective cancer ...

We led major clinical trials in radiotherapy and imaging which have changed standard clinical practice for cancer treatment.

We provided the first conclusive evidence that the basic cause of cancer is damage to DNA. The discovery changed scientific opinion dramatically and marked a turning point for cancer research.

We played a major role in characterising the BRAF gene and its role in cancer, increasing our understanding of malignant melanoma.

We pioneered the application of evolutionary biology to cancer and established cancer stem cells as the units of natural selection.

Professor Eeles's goal is to develop new tests that could be used in prostate cancer screening, helping to identify men at a ...

We identified the breast cancer gene BRCA2, which enabled families with a history of breast cancer to be assessed for future risk, and laid the groundwork for developing novel forms of therapy for ...

Metastatic cells are characterised as being highly invasive but weakly adhesive with rounded-amoeboid like features. These cells harbour high levels of cortical Myosin II activity and exert low ...

Through studies that were amongst the largest of their kind, we identified several genes involved in breast and/or ovarian cancer predisposition such as CHEK2, BRIP1, ATM, PALB2, RAD51C and RAD51D.