Drug resistance is a major clinical challenge in cancer treatment, underlying both tumour recurrence and patient mortality (Vasan et al, 2019). Yet when cancer cells develop resistance to a drug, ...

Cancer development is fundamentally an evolutionary process, however monitoring evolutionary dynamics through treatment remains challenging. Our team have recently developed a new methodology that can ...

Multiple myeloma (MM) affects over 5,500 people annually in the UK, with a 5-year survival rate below 50% in advanced stages. Resistance to therapies is driven by transcriptional addiction, where ...

The Royal Marsden NHS Foundation Trust is a world-leading specialist cancer hospital. The Institute of Cancer Research works in close partnership with The Royal Marsden to take the results of our ...

We have an outstanding record of scientific achievement dating back more than 100 years. Here are some of our most influential discoveries, all of which have played an important role in shaping our ...

Through studies that were amongst the largest of their kind, we identified several genes involved in breast and/or ovarian cancer predisposition such as CHEK2, BRIP1, ATM, PALB2, RAD51C and RAD51D.

We provided the first conclusive evidence that the basic cause of cancer is damage to DNA. The discovery changed scientific opinion dramatically and marked a turning point for cancer research.

We pioneered the application of evolutionary biology to cancer and established cancer stem cells as the units of natural selection.

We transformed care for advanced prostate cancer, by validating inhibitors of androgen production as an effective cancer ...

We applied the principle of synthetic lethality to discover a novel strategy for cancer treatment for patients with BRCA1 or ...

PI3 kinase is a lipid signalling enzyme which plays a key role in the development and progression of many cancers as a result ...

We played a major role in characterising the BRAF gene and its role in cancer, increasing our understanding of malignant melanoma.